Melatonin do thân thể chúng ta sản xuất. Sự sản xuất bắt đầu khi mặt trời lặn để làm cho chúng ta buồn ngủ.
Melatonin đóng vai trò quan trọng trong việc điều hòa chu kỳ “ngủ-thức” giúp chúng ta ngủ và thức dậy mỗi ngày theo một giờ giấc cố định và giấc ngủ ngon và khỏe khoắn.
Trong nhiều năm qua, Melatonin được biết là thuốc thiên nhiên, giúp ta ngủ ngon giấc và có thể chống lại chứng mất ngủ bất thường xảy ra.
Nó là chất kích thích tố tự nhiên chớ không phải là thuốc nên không có phản ứng phụ hoặc gây nghiện.
Mới đây, khi Tổng Thống Donal Trump bị nhiểm Covid-19, bác sĩ cho Tổng Thống dùng Melatonin để chống dịch và chóng phục hồi.
Ngày 25 tháng 1, 2021 vừa qua, các nhà nghiên cứu Trường Đại Học Y Khoa Tokyo, Nhật Bản cho biết Melatonin có hiệu quả phục hồi trí nhớ và chống lại bệnh Alzheimer (xem phía dưới).
Nếu thuốc ngủ Melatonin giúp chúng ta ngủ ngon giấc, chống bệnh mất trí nhớ và Covid-19 thì tuyệt quá.
Nếu muốn dùng thử Melatonin, các bạn nên mua Melatonin sản xuất bởi công ty Mỹ như NATROL, California.
Ở Costco đang bán chai Melatonin này. Lúc sale chỉ có $6.99 chai 250 viên ngậm tan trong miệng trước khi ngủ 30′
Finally, a Supplement That Actually Boosts Memory – Many Already Take It for Better Sleep
TOPICS: Alzheimer’sMemoryNeuroscienceTokyo Medical And Dental University
By TOKYO MEDICAL AND DENTAL UNIVERSITY JANUARY 25, 2021
Researchers at Tokyo Medical and Dental University (TMDU) in Japan show that melatonin and its metabolites promote the formation of long-term memories in mice and protect against cognitive decline.
Researchers at Tokyo Medical and Dental University (TMDU) showed that melatonin’s metabolite AMK can enhance the formation of long-term memories in mice. Memory of objects were tested after treatment with melatonin or two of its metabolites. Older mice that normally performed poorly on the memory task showed improvements as dosage increased. The metabolite AMK was found to be the most important as melatonin failed to improve memory if it was blocked from metabolizing into AMK.
Walk down the supplement aisle in your local drugstore and you’ll find fish oil, ginkgo, vitamin E, and ginseng, all touted as memory boosters that can help you avoid cognitive decline. You’ll also find melatonin, which is sold primarily in the United States as a sleep supplement. It now looks like melatonin marketers might have to do a rethink. In a new study, researchers led by Atsuhiko Hattori at Tokyo Medical and Dental University (TMDU) in Japan have shown that melatonin and two of its metabolites help memories stick around in the brain and can shield mice, and potentially people, from cognitive decline.
One of the easiest ways to test memory in mice is to rely on their natural tendency to examine unfamiliar objects. Given a choice, they’ll spend more time checking out unfamiliar objects than familiar ones. The trick is that for something to be familiar, it has to be remembered. Like in people, cognitive decline in mice manifests as poor memory, and when tested on this novel object recognition task, they behave as if both objects are new.
Three 1-minute training trials (A) revealed age-associated object memory decline in middle-aged and old mice at 1 day post-training (B). Systemic AMK (1 mg/kg) administered after a single 1-minute training trial enhanced object memory at 1 and 4 days post-training in all age groups (D-F). Data are presented as mean ± standard error. *P < .05 and **P < .01 indicate significantly different than chance performance (50%). Discrimination index (%) = time exploring novel object/ total object exploration time during test X 100. Credit: Department of Biology,TMDU
The group of researchers at TMDU were curious about melatonin’s metabolites, the molecules that melatonin is broken down into after entering the body. “We know that melatonin is converted into N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-
methoxykynuramine (AMK) in the brain,” explains Hattori, “and we suspected that they might promote cognition.” To test their hypothesis, the researchers familiarized mice to objects and gave them doses of melatonin and the two metabolites 1 hour later. Then, they tested their memory the next day. They found that memory improved after treatment, and that AMK was the most effective. All three accumulated in the hippocampal region of the brain, a region important for turning experiences into memories.
For young mice, exposure to an object three times in a day is enough for it to be remembered the next day on the novel object recognition task. In contrast, older mice behave as if both objects are new and unfamiliar, a sign of cognitive decline. However, one dose of AMK 15 min after a single exposure to an object, and older mice were able to remember the objects up to 4 days later.
Lastly, the researchers found that long-term memory formation could not be enhanced after blocking melatonin from being converted into AMK in the brain. “We have shown that melatonin’s metabolite AMK can facilitate memory formation in all ages of mice,” says Hattori. “Its effect on older mice is particularly encouraging and we are hopeful that future studies will show similar effects in older people. If this happens, AMK therapy could eventually be used to reduce the severity of Mild Cognitive Impairment and its potential conversion to Alzheimer’s disease.”
Reference: “The melatonin metabolite N1‐acetyl‐5‐methoxykynuramine facilitates long‐term object memory in young and aging mice” by Hikaru Iwashita, Yukihisa Matsumoto, Yusuke Maruyama, Kazuki Watanabe, Atsuhiko Chiba and Atsuhiko Hattori, 30 October 2020, Journal of Pineal Research